During the last years the genomic revolution has provide unique research opportunities unthought-of before. Our laboratory is focused in the study of genome evolution and the genetic changes associated with individual and species differences, applying the newest genomic techniques and the great wealth of genomic data available. In particular, a great degree of structural variation, including hundreds of copy number variants (insertions, duplications and deletions) and inversions have been discovered in multiple organisms. In addition, we now have the information of the variation of expression levels of thousands of genes in different tissues and individuals of many species. However, we still know very little about the functional consequences of these changes and the role that might have played during evolution. To address these questions, we use humans as a model and take a multidisciplinary approach that combines experimental and bioinformatic analysis, generating results of interest to diverse fields.
Our group was created in 2010 and is part of the Genomics Unit of the Institut de Biotecnologia i de Biomedicina (IBB), which is a multidisciplinary and international research center of the Universitat AutĂ˛noma de Barcelona (UAB). Our laboratory is located in the neighboring IBB and the MRB buildings, with separate spaces for the experimental and bioinformatic work. We are included within the Genomics, Bioinformatics and Evolution group of the UAB, and collaborate closely with other researchers in the Barcelona area, such as Xavier Estivill of the Centre for Genomic Regulation (CRG), Juan R GonzĂˇlez of the Centre for Research in Environmental Epidemiology (CREAL), and TomĂ s MarquĂ©s-Bonet of the Institute of Evolutionary Biology (IBE), as well as with other international groups and projects.