Meiosis is the specialized cell division by which haploid germ cells are produced from a diploid progenitors. This is accomplished by passing through two rounds of cell division after a single replication of the genome. In the first meiotic division, in mammals, around 250 double strand breaks (DSBs) are produced along the genome. Repair of those DSBs by homologous recombination leads to the pairing and synapsis of the homologous chromosomes. Moreover, homologous recombination also promotes the exchange of DNA sequences between the homologs, known as crossovers. All these processes are crucial for the proper progression of meiosis. Furthermore, it is also indispensable for the perpetuation of the species that DSBs are accurately repaired during meiosis. Therefore, these processes are tightly regulated and controlled by mechanisms that detect when errors are produced. Nowadays, some of these mechanisms are known, although the proteins involved in them are not identified.
The main goal of the research group is to study using genetic approaches the mechanisms that control meiotic progression in the mouse as well as identify the proteins involved in these mechanisms.