Selected publications (2008-2014; see PI Resume for an extended publication record):

Dios S, Balseiro P, Costa MM, Romero A, Boltaña S, Roher N, Mackenzie S, Figueras A, Novoa B. The Involvement of Cholesterol in Sepsis and Tolerance to Lipopolysaccharide Highlighted by the Transcriptome Analysis of Zebrafish (Danio rerio). Zebrafish. 2014 Sep 2. [Epub ahead of print]. 


Two different rpf clusters distributed among a population of Stenotrophomonas maltophilia clinical strains display differential DSF production and virulence regulation.

Huedo P, Yero D, Martínez-Servat S, Estibariz I, Planell R, Martínez P, Ruyra A, Roher N, Roca I, Vila J, Daura X, Gibert I. J Bacteriol. 2014 Apr 25. [Epub ahead of print].

Eduardo Jiménez-Fernández, Angels Ruyra, Nerea Roher, Eugenia Zuasti, Carlos Infante and Catalina Fernández-Díaz. Nanoparticles as a novel delivery system for Vitamin C administration in aquaculture. Aquaculture (2014) Accepted.

A. Ruyra, M. Cano-Sarabia, P. Gracia-Valtanen, D. Yero, I. Gibert, SA. Mackenzie, A. Estepa, D.  Maspoch and N. Roher. Targeting and stimulation of the zebrafish (Danio rerio) innate immune system with LPS/dsRNA-loaded nanoliposomes.Vaccine (2014) Jun 30;32(31):3955-62. doi: 10.1016/j.vaccine.2014.05.010. Epub 2014 May 14.

Ruyra A., Cano MA., Mackenzie SA., Maspoch D., Roher N. A novel liposome-based nanocarrier loaded with an LPS-dsRNA cocktail for fish innate immune system stimulation. Accepted in PlosOne (2013).

Callol A, Roher N., Amaro C., Mackenzie,SA. Characterization of PAMP/PRR interactions in European eel (Anguilla anguilla) macrophage-like primary cell cultures. Fish and Shellfish Immunology doi:pii: /j.fsi.2013.07.037 (2013).

Boltaña S., ReyS., RoherN., VargasR., HuertaM., HuntingfordFA., GoetzFW., MooreJ., Garcia-ValtanenP., Estepa A. and MacKenzie S. Behavioural fever is a synergic signal amplifying the innate immune response. Proceedings of the Royal Society B Sep 7;280(1766):20131381 (2013)

Ferrer-Navarro M., PlanellR., YeroD., MongiardiniE., TorrentG., HuedoP., MartínezP., RoherN., MackenzieS., GibertI., DauraX.. Abundance of the Quorum-Sensing Factor Ax21 in Four Strains of Stenotrophomonas maltophilia Correlates with Mortality Rate in a New Zebrafish Model of Infection. PlosOne; 8 (6):e67207 (2013).

Crespo, D., Mañanos, EL., Roher, N., MacKenzie, SA., and Planas, JV. Tumor necrosis factor α may act as an intra-ovarian mediator of luteinizing hormone-induced oocyte maturation in trout. Biol Reprod. 86(1):1-12 (2012).

Morera D, Roher N, Ribas L, Balasch JC, Doñate C, Callol A, Boltaña S, Roberts S, Goetz G, Goetz FW,MacKenzie S. RNA-Seq reveals an integrated immune response in nucleated erythrocytes. PLoS One. 6(10):e26998 (2011).

Boltaña S, Roher N, Goetz FW, Mackenzie SA. PAMPs, PRRs and the genomics of gram negative bacterial recognition in fish. Dev Comp Immunol. 35(12):1195-203(2011).

Mauri I, Roher N, MacKenzie S, Romero A, Manchado M, Balasch JC, Béjar J, Alvarez MC, Tort L. Molecular cloning and characterization of European seabass (Dicentrarchus labrax) and Gilthead seabream (Sparus aurata) complement component C3. Fish Shellfish Immunol. 30(6):1310-22 (2011).

Vraskou Y, Roher N, Díaz M, Antonescu CN, MacKenzie SA, Planas JV. Direct involvement of tumor necrosis factor α in the regulation of glucose uptake in rainbow trout muscle cells. Am J Physiol Regul Integr Comp Physiol. 300(3):R716-23 (2011).

Roher N., Callol A., Planas JV., Goetz FW. and MacKenzie SA. Shedding of TNFα by TACE/ADAM17-like activity in fish is conserved throughout evolution and regulation of TNFα secretion does not contribute to LPS tolerance.  Innate Immun. 17(1):16-28 (2011).

Mackenzie S.*, Roher N.*, Boltaña S., GoetzFW. Peptidoglycan, not endotoxin, is the key mediator of cytokine gene expression induced in trout macrophages by crude LPS.  Mol Immunol. 47(7-8):1450-7 (2010). * both authors contributed equally.

MacKenzie S, Balasch JC, Novoa B, Ribas L, Roher N, Krasnov A, Figueras A. Comparative analysis of the acute response of the trout, O. mykiss, head kidney to in vivo challenge with virulent and attenuated infections hematopoietic necrosis virus and LPS-induced inflammation. BMC Genomics 26, 9:141 (2008).

Roher N, Samokhvalov V, Díaz M, Mackenzie S, Klip A, Planas JV. The proinflammatory cytokine TNFα increases the amount of GLUT4 at the surface of muscle cells independently of changes in IL-6. Endocrinology 149, 1880-9 (2008).

Campus d'excel·lència internacional U A B