Define the mechanism that controls the evolution of DSB repair during meiosis.

DSB repair deffective spermatocyteDSB repair deffective spermatocyte

Most if not all mutant mice that fail to repair DSBs are sterile. Both oocytes and spermatocytes have mechanisms that control how the DSB repair goes. Although this has been known for quite some time, little is know about the exact mechanism/s that preform this function. Therefore, the main goal of this research line is to identify the key players of this mechanism and genetically demonstrate their function. Recent studies have suggested that key players of the machinery that controls DSB repair in somatic cells are activated during meiosis. Thus, we will firstly focus on studying the possible role of these proteins during meiosis and the their status in DSB-repair deficient meiocytes.   


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